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Publication Date: 06 Sep 2007
Journal: Evolutionary Bioinformatics 2007:3 159-168
Abstract Kazuharu Arakawa and Masaru Tomita
Institute for Advanced Biosciences, Keio University, Fujisawa, Kanagawa 252-8520, Japan.
Abstract: Circular bacterial chromosomes have highly polarized nucleotide composition in the two replichores, and this genomic strand asymmetry can be visualized using GC skew graphs. Here we propose and discuss the GC skew index (GCSI) for the quantification of genomic compositional skew, which combines a normalized measure of fast Fourier transform to capture the shape of the skew graph and Euclidean distance between the two vertices in a cumulative skew graph to represent the degree of skew. We calculated GCSI for all available bacterial genomes, and GCSI correlated well with the visibility of GC skew. This novel index is useful for estimating confi dence levels for the prediction of replication origin and terminus by methods based on GC skew and for measuring the strength of replicational selection in a genome.
It was a pleasure participating as a reviewer for Clinical Medicine Insights: Case Reports. The online access was smooth and very user-friendly. The navigation process for submission of reviewer comments was flawless.Overall, a very pleasant process. The case report that I reviewed was a very interesting one, very well written and with many interesting points for readers.Associate Professor Macaulay Onuigbo, MD MSc FWACP FASN (Associate Professor, College of Medicine, Mayo Clinic, Rochester, MN Nephrologist/Transplant, Physician/Hypertension Specialist, Midelfort Clinic, Mayo Health System, Eau Claire, WI, Regional Direct) What our authors say
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