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Abstract Pancreatic adenocarcinoma is an aggressive cancer with a greater than 95% mortality rate and short survival after diagnosis. Chemotherapeutic resistance hinders successful treatment. This resistance is often associated with mutations in codon 12 of the K-Ras gene (K-Ras 12), which is present in over 90% of all pancreatic adenocarcinomas. Codon 12 mutations maintain Ras in a constitutively active state leading to continuous cellular proliferation. Our study determined if TRAIL resistance in pancreatic adenocarcinomas with K-Ras 12 mutations could be overcome by first sensitizing the cells with Benzyl isothiocyanate (BITC). BITC is a component of cruciferous vegetables and a cell cycle inhibitor. BxPC3, MiaPaCa2 and Panc-1 human pancreatic adenocarcinoma cell lines were examined for TRAIL resistance. Our studies show BITC induced TRAIL sensitization by dual activation of both the extrinsic and intrinsic apoptotic pathways.
As an open access journal with an international audience, Air, Soil and Water Research has a tremendous worldwide impact. Peer reviewing process is essential to maintain the high standard of quality of published papers, and I have thoroughly enjoyed my participation as a reviewer for Air, Soil and Water Research. The online review system is very easy and simply to use. I am looking forward to peer reviewing additional articles in the future.Dr Dionisis Gasparatos (Agricultural University of Athens, Athens, Greece) What our authors say
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