Close
Help




JOURNAL

Clinical Medicine Insights: Therapeutics

505,546 Journal Article Views | Journal Analytics

Ceftobiprole: An Emerging Therapeutic Option for Resistant and Complicated Infections

Submit a Paper



Publication Date: 06 Feb 2011

Type: Review

Journal: Clinical Medicine Insights: Therapeutics

Citation: Clinical Medicine Insights: Therapeutics 2011:3 57-66

doi: 10.4137/CMT.S5032

Abstract

Ceftobiprole is a new parenterally administered fifth generation cephalosporin which has been shown to have antimicrobial activity against a broad range of bacteria, and specifically against methicillin-resistant Staphylococcus aureus (MRSA) in complicated skin and skin structure infections (cSSSIs), with a cure rate non-inferior to vancomycin and ceftazidime. It has increased stability against β-lactamases and an increased affinity for PBP2 in MRSA strains. Ceftobiprole has shown a low tendency to select for resistance, and because it is excreted mainly in the urine, a low potential for adverse drug interactions. It has been shown to cause few mild to moderate adverse effects in patients. The broad-spectrum of activity makes it an excellent choice for initial monotherapy in cSSSIs. There is also promise for use in all types of pneumonia, and synergistic possibilities with aminoglycoside and fluoroquinolone drugs. It is awaiting final approval by the FDA.


Downloads

PDF  (529.03 KB PDF FORMAT)

RIS citation   (ENDNOTE, REFERENCE MANAGER, PROCITE, REFWORKS)

BibTex citation   (BIBDESK, LATEX)






What Your Colleagues Say About Clinical Medicine Insights: Therapeutics
Traditional vehicles of medical publication could learn constructive lessons of efficiency from the editors of Libertas Academica!
Dr Charles Burger (Professor of Medicine, Mayo Clinic, Jacksonville, Florida, USA)
More Testimonials

Quick Links


New article and journal news notification services