Publication Date: 09 Jul 2012
Type: Original Research
Journal: Biochemistry Insights
Citation: Biochemistry Insights 2012:5 11-15
doi: 10.4137/BCI.S9824
Chemo-enzymatic synthesis of glycolyl-ester-linked taxol-glucose conjugate, ie, 7-glycolyltaxol 2"-O-α-D-glucoside, was achieved by using α-glucosidase as a biocatalyst. The water-solubility of 7-glycolyltaxol 2"-O-α-D-glucoside (21 µM) was 53 fold higher than that of taxol. The hepatitis B virus envelope L particles (bio-nanocapsules) are effective for delivering 7-glycolyltaxol 2"-O-α-D-glucoside to human hepatocellular carcinoma NuE cells.
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