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Biochemistry Insights

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Chemo-Enzymatic Synthesis of Glycolyl-Ester-Linked Taxol-Monosaccharide Conjugate and Its Drug Delivery System Using Hepatitis B Virus Envelope L Bio-Nanocapsules

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Publication Date: 09 Jul 2012

Type: Original Research

Journal: Biochemistry Insights

Citation: Biochemistry Insights 2012:5 11-15

doi: 10.4137/BCI.S9824

Abstract

Chemo-enzymatic synthesis of glycolyl-ester-linked taxol-glucose conjugate, ie, 7-glycolyltaxol 2"-O-α-D-glucoside, was achieved by using α-glucosidase as a biocatalyst. The water-solubility of 7-glycolyltaxol 2"-O-α-D-glucoside (21 µM) was 53 fold higher than that of taxol. The hepatitis B virus envelope L particles (bio-nanocapsules) are effective for delivering 7-glycolyltaxol 2"-O-α-D-glucoside to human hepatocellular carcinoma NuE cells.


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