Gene Regulation and Systems Biology

Critical Self-Organized Self-Sustained Oscillations in Large Regulatory Networks: Towards Understanding the Gene Expression Initiation

Submit a Paper

Gene Regulation and Systems Biology 2011:5 27-40

Original Research

Published on 22 Mar 2011

DOI: 10.4137/GRSB.S6804

Further metadata provided in PDF

Sign up for Email Alerts and keep in touch with Gene Regulation and Systems Biology journal news, updates, events and articles


In this paper, a new model of self-organized criticality is introduced. This model, called the gene expression paradigm, is motivated by the problem of gene expression initiation in the newly-born daughter cells after mitosis. The model is fundamentally different in dynamics and properties from the well known sand-pile paradigm. Simulation experiments demonstrate that a critical total number of proteins exists below which transcription is impossible. Above this critical threshold, the system enters the regime of self-sustained oscillations with standard deviations and periods proportional to the genes' complexities with probability one. The borderline between these two regimes is very sharp. Importantly, such a self-organization emerges without any deterministic feedback loops or external supervision, and is a result of completely random redistribution of proteins between inactive genes. Given the size of the genome, the domain of self-organized oscillatory motion is also limited by the genes' maximal complexities. Below the critical complexity, all the regimes of self-organized oscillations are self-similar and largely independent of the genes' complexities. Above the level of critical complexity, the whole-genome transcription is impossible. Again, the borderline between the domains of oscillations and quiescence is very sharp. The gene expression paradigm is an example of cellular automata with the domain of application potentially far beyond its biological context. The model seems to be simple enough for staging an experiment for verification of its remarkable properties.




BibTex citation   (BIBDESK, LATEX)


What Your Colleagues Say About Gene Regulation and Systems Biology
The reviewing and editorial management of our paper was timely, thorough, and systematic.  In particular the reviewers' comments resulted in a paper significantly more robust than the first version.
Dr Clark D Jeffries (University of North Carolina at Chapel Hill, Chapel Hill, NC, USA)
More Testimonials

Quick Links

New article and journal news notification services