Need Help?


Bioinformatics and Biology Insights

552,918 Journal Article Views | Journal Analytics

DNA Structural Properties in the Classification of Genomic Transcription Regulation Elements

Submit a Paper

Publication Date: 02 Jul 2012

Type: Review

Journal: Bioinformatics and Biology Insights

Citation: Bioinformatics and Biology Insights 2012:6 155-168

doi: 10.4137/BBI.S9426


It has been long known that DNA molecules encode information at various levels. The most basic level comprises the base sequence itself and is primarily important for the encoding of proteins and direct base recognition by DNA-binding proteins. A more elusive level consists of the local structural properties of the DNA molecule wherein the DNA sequence only plays an indirect supportive role. These properties are nevertheless an important factor in a large number of biomolecular processes and can be considered as informative signals for the presence of a variety of genomic features. Several recent studies have unequivocally shown the benefit of relying on such DNA properties for modeling and predicting genomic features as diverse as transcription start sites, transcription factor binding sites, or nucleosome occupancy. This review is meant to provide an overview of the key aspects of these DNA conformational and physicochemical properties. To illustrate their potential added value compared to relying solely on the nucleotide sequence in genomics studies, we discuss their application in research on transcription regulation mechanisms as representative cases.




BibTex citation   (BIBDESK, LATEX)


What Your Colleagues Say About Bioinformatics and Biology Insights
Bioinformatics and Biology Insights fills a gap in current journals.  Ever more often, bioinformatics and detailed analysis of data creates novel, unexpected insights.  It is good to have a journal which focusses on exactly this aspect of bioinformatics research, putting the biology insights upfront with high respect for the different methods in bioinformatics.
Dr Thomas Dandekar (University of Wurzburg, European Molecular Biology Laboratory, Heidelberg, Germany)
More Testimonials

Quick Links

Follow Us We make it easy to find new research papers.

Author Survey Results
All authors are surveyed after their articles are published. Authors are asked to rate their experience in a variety of areas, and their responses help us to monitor our performance. Presented here are their responses in some key areas. No 'poor' or 'very poor' responses were received; these are represented in the 'other' category.
See Our Results