Clinical Medicine Reviews in Vascular Health

Adequate control of lipids is a cornerstone in the management of coronary heart disease. Numerous studies have demonstrated the effectiveness of HMG-Co A reductase inhibitors (statins) in controlling LDL-C. Unfortunately, the effect of statins on other lipid parameters, such as HDL-C and triglycerides, is not as robust. Emerging evidence suggests that these other lipid parameters may contribute to residual cardiovascular risk. The recent release of fenofibric acid offers a potential therapy which can be used in conjunction with statins to achieve an optimal lipid profile. Clinical trials have demonstrated fenofibric acid to be safe for use as dual therapy with low and moderate dose statins. The following article will address the safety and efficacy of fenofibric acid in the treatment of lipid disorders, both alone and as combination therapy with statins. Additionally, the potential role of fenofibric acid in the management of the complex cardiovascular patient with abnormal lipid parameters will be evaluated.