Close
Help





JOURNAL

Evolutionary Bioinformatics

FORS-D Analysis in P. falciparum can Differentiate Classes of Genes Under Selection

Submit a Paper


Evolutionary Bioinformatics 2011:7 21-29

Original Research

Published on 20 Mar 2011

DOI: 10.4137/EBO.S6609


Further metadata provided in PDF



Sign up for Email Alerts and keep in touch with Evolutionary Bioinformatics journal news, updates, events and articles

Abstract

FORS-D is a measure of the contribution of base order to the stem loop potential of a nucleic acid sequence and can also give information on evolutionary pressures on sequences to move away from secondary structure. Negative FORS-D values in a gene are associated with exons and nucleotide substitutions such as SNPs. An analysis of P. falciparum genes under selection pressure shows a correlation between negative FORS-D values and SNP density for genes that drug targets but not for drug transporters or antigenic variation genes. Analysis of the dhfr gene shows that a majority of rare mutations that associate with drug resistance also fall into regions with negative FORS-D values. These data suggest that FORS-D values might be predictors for drug target genes and drug resistance mutations in these genes.



Downloads

PDF  (551.39 KB PDF FORMAT)

RIS citation   (ENDNOTE, REFERENCE MANAGER, PROCITE, REFWORKS)

BibTex citation   (BIBDESK, LATEX)

XML




What Your Colleagues Say About Evolutionary Bioinformatics
This is the fastest progress we have experienced from submission to acceptance.  Reviews are fast, pertinent, and instructive.  Every step of the process is visible and prompt, and every email is friendly and immediate.  In all, it is an excellent experience to be published in Libertas Academica.
Dr Jiang Wang (Sun Yat sen University, Guangzhou, P.R. China.)
More Testimonials

Quick Links


New article and journal news notification services