Medicine
Open access articles in medicine. Articles from all journals publishing articles on clinical medicine.
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Latest articles
- Glycosaminoglycans in Human and Bovine Serum: Detection of Twenty-Four Heparan Sulfate and Chondroitin Sulfate Motifs Including a Novel Sialic Acid-Modified Chondroitin Sulfate Linkage Hexasaccharide
- Antiplasmodial Activity of Some Medicinal Plants Used in Sudanese Folk-medicine
- A Robust Gene Selection Method for Microarray-based Cancer Classification
- Enzymatic Synthesis and Anti-Allergic Activities of Curcumin Oligosaccharides
- Bimodal Gene Expression and Biomarker Discovery
- Nicolau Syndrome: A Review of the Literature
- Valvular Aortic Stenosis: A Proteomic Insight
- An Improved Approach for Mapping Quantitative Trait Loci in a Pseudo-Testcross: Revisiting a Poplar Mapping Study
- ETS-FUSions Networking, Triggering and Beyond
- Single Nucleotide Polymorphisms Caused by Assembly Errors
- Quetiapine Induced Acute Dystonia in a Patient with History of Severe Head Injury
- Spectral Domain OCT Documented Resolution of Pseudophakic Cystoid Macular Edema after Intravitreal Triamcinolone
- Liquid Chromatography with Post-Column Reagent Addition of Ammonia in Methanol Coupled to Negative Ion Electrospray Ionization Tandem Mass Spectrometry for Determination of Phenoxyacid Herbicides and their Degradation Products in Surface Water
- Local Cell Proliferation Upon Enucleation in Direct Retinal Brain Targets in the Visual System of the Adult Mouse
- Correlation Between Peroxisome Proliferation and Up-Regulation of Cytochrome P450 CYP4A and Peroxisomal Beta-Oxidation Fatty Acyl CoA Oxidases (AOX) in the Koala (Phascolarctos Cinereus)
- Methadone Cardiotoxicity in Pain Management—An Important Issue for Clinicians
- Identification of Chemically Sulfated/desulfated Glycosaminoglycans in Contaminated Heparins and Development of a Simple Assay for the Detection of Most Contaminants in Heparin
- Chronic Pain of the Vulva without Dermatologic Manifestations: Distinguishing Among a Spectrum of Clinical Disorders
- A Pain-free Lancet with a Small Needle for Glucose Measurement
- Assessment of Confounding Factors Affecting the Tumor Markers SMRP, CA125, and CYFRA21-1 in Serum
Most read articles
- Relationship Between the Plasma Concentration of C-Reactive Protein and Severity of Peripheral Arterial Disease
- Current Status of Monocyte Differentiation-Inducing (MDI) Factors Derived from Human Fetal Membrane Chorion Cells Undergoing Apoptosis after Influenza Virus Infection
- Intraspecific ITS Variability in the Kingdom Fungi as Expressed in the International Sequence Databases and Its Implications for Molecular Species Identification
- A Simple Derivation of the Distribution of Pairwise Local Protein Sequence Alignment Scores
- DICOM Structured Reporting and Cancer Clinical Trials Results
- Mammoth and Elephant Phylogenetic Relationships: Mammut Americanum, the Missing Outgroup
- Evaluation of Two Outlier-Detection-Based Methods for Detecting Tissue-Selective Genes from Microarray Data
- Systems Biology-Based Identification of Crosstalk between E2F Transcription Factors and the Fanconi Anemia Pathway
- Exploring the Evolutionary History of the Differentially Expressed Genes between Human Populations: Action of Recent Positive Selection
- On the Adaptive Design Rules of Biochemical Networks in Evolution
- Phylogenetic diversity (PD) and biodiversity conservation: some bioinformatics challenges
- Fast Genes and Slow Clades: Comparative Rates of Molecular Evolution in Mammals
- Identification and Quantitation of Asparagine and Citrulline Using High-Performance Liquid Chromatography (HPLC)
- Clinical Presentation and Histologic Findings at Ileocolonoscopy in Children with Autistic Spectrum Disorder and Chronic Gastrointestinal Symptoms
- In Silico Promoter Analysis can Predict Genes of Functional Relevance in Cell Proliferation: Validation in a Colon Cancer Model
(previous 30 days)Site updates
Breast Cancer: Basic and Clinical Research
Orbital Metastasis of Breast Carcinoma (02/Dec/2009)
We report a case of orbital metastasis in a previously diagnosed metastatic breast cancer in a 46-year old woman presenting with diplopia and proptosis of her left eye bulb. An orbital computed-tomography (CT) and a magnetic resonance imaging (MRI) both revealed an intra-orbital extra-bulbar mass of 1.5 × 3 cm in size, in the left orbit. The patient had been diagnosed with stage IV breast cancer 4 years before. She had received chemotherapy with docetaxel...
Characterization of a Test for Invasive Breast Cancer Using X-ray Diffraction of Hair - Results of a Clinical Trial (10/Nov/2009)
Objective: To assess the performance of a test for breast cancer utilizing synchrotron x-ray diffraction analysis of scalp hair from women undergoing diagnostic radiology assessment. Design and Setting: A double-blinded clinical trial of women who attended diagnostic radiology clinics in Australia. Patients: 1796 women referred for diagnostic radiology, with no previous history...
Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders
The Influence of Traditional Herbal Medicine (Kampo) on Anti-cyclic Citrullinated Peptide Antibody Levels (17/Sep/2009)
We present three rheumatoid arthritis (RA) patients successfully treated with traditional herbal medicine (THM: Kampo). The treatment with THM resulted in a decrease in RA disease activity such as DAS28, as well as in the serum levels of anti-cyclic citrullinated peptide antibodies (anti-CCP) in 3 cases. These observations suggest that...
A 47-year-old woman demonstrated bilateral wrist joint pain during 4 weeks. Her status did not fulfill the ACR classification criteria for RA, and her symptoms had almost disappeared 4 weeks later. After about 1 year, she again complained of tenderness and swelling in the bilateral wrist joints. The laboratory data...
Clinical Medicine Insights: Blood Disorders
Castleman’s Disease: A Study of A Rare Lymphoproliferative Disorder In A University Hospital (06/Jul/2009)
Castleman’s disease (CD) is a group of rare lymphoproliferative disorders sharing characteristic clinical and histological features, and usually accompanied by a marked systemic inflammatory response. Three histological patterns of lymph nodes were described: the hyaline-vascular, the plasma-cell and the mixed types. The former is more common (80%–90%) and tends to be localized. The plasma cell type is more aggressive and usually multicentric. It is interesting that the inflammatory manifestations seem to be related to a...
Birth MCV and MCH are Quite Reliable Parameters for the Prediction of Alpha Thalassemia Trait (13/May/2009)
To assess some simple blood parameters at birth that can be used as a basis to suspect α-thalassemia minor (ATM), a prospective study involving 202 consecutive neonates with MCV of less than 95 fl or less were checked for Hb Barts by HPLC. The group was divided into two, one...
Clinical Medicine Insights: Cardiology
Valvular Aortic Stenosis: A Proteomic Insight (04/Feb/2010)
Calcified aortic valve disease is a slowly progressive disorder that ranges from mild valve thickening with no obstruction of blood flow, known as aortic sclerosis, to severe calcification with impaired leaflet motion or aortic stenosis. In the present work we describe a rapid, reproducible and effective method to carry out...
Valvular Aortic Stenosis: A Proteomic Insight (04/Feb/2010)
Calcified aortic valve disease is a slowly progressive disorder that ranges from mild valve thickening with no obstruction of blood flow, known as aortic sclerosis, to severe calcification with impaired leaflet motion or aortic stenosis. In the present work we describe a rapid, reproducible and effective method to carry out...
Clinical Medicine Insights: Case Reports
A Case of Protruding Eyeballs and Diminishing Vision (20/Jan/2010)
This case report discusses issues related to a 56-year-old man from Bangalore who presented with complaints of a gradual protrusion of his eyeballs along with diminishing vision for the previous month. The approach to diagnosis and management issues around this unusual presentation is discussed.
Common Variable Immunodeficiency Associated with Inflammatory Bowel Disease and Type I Diabetes (27/Nov/2009)
Common variable immunodeficiency (CVID) is a heterogeneous group of primary immunodeficiency disorders characterized by defective antibody production, low levels of serum immunoglobulins and increased susceptibility to infection. The patient was a 39-year-old male who was admitted to the gastroenterology department with a two week history of diarrhea, blunt abdominal pain...
Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine
Gene Variant of the Bradykinin B2 Receptor Influences Pulmonary Arterial Pressures in Heart Failure Patients (17/Feb/2009)
Background: Pulmonary arterial pressure (PAP) varies considerably in heart failure (HF) despite similar degrees of left ventricular (LV) dysfunction. Bradykinin alters vascular tone and common variations in the kinin B2 receptor (BDKRB2) gene exists. We hypothesized that genetic variation in this receptor would influence PAP in HF. Methods: 131...
Risk Factors for a Second Episode of Hemoptysis (09/Feb/2009)
Objectives: Hemoptysis is an alarming symptom of underlying lung disease. Clinicians are often unsure how to deal with and follow up patients who have had a single episode of hemoptysis, especially if the cause remains unknown despite thorough examination, because a second, more severe episode of hemoptysis might occur despite...
Clinical Medicine Insights: Dermatology
Nicolau Syndrome: A Review of the Literature (04/Feb/2010)
Nicolau Syndrome, first described in the 1920’s in patients treated with bismuth salts for syphilis, is a rare adverse reaction at the site of intramuscular drug injection. It is clinically characterized by severe pain immediately after injection, and rapid development of blanched skin or livedoid reticular patches. Occlusion of peripheral...
Crossplasty is a modified O-T advancement flap. It is an alternative technique to close double surgical defects, which are arranged in a vertical line. It is useful to camouflage the scar in forehead parallel lines. Geometrically, it is an inverted T joined to a vertical linear defect. There are three...
Clinical Medicine Insights: Ear, Nose and Throat
Hemangioma of the Thyroid (18/Sep/2009)
Introduction: Thyroid hemangioma is very rare, and only a few cases have previously been reported. We encountered a patient with thyroid hemangioma diagnosed after surgery. Case Report: A 71‑year‑old woman visited our hospital with a mass in the left thyroid region. A 5‑cm, elastic mass of the thyroid was palpable in...
The Role of sFas in the Immune Escape Mechanism and Progression of Cancer Larynx (21/Jul/2009)
This work assess serum levels of soluble Fas form (sFas) in patients with different stages of laryngeal squamous cell carcinoma (LSCC) to investigate its prognostic significance. We correlate its levels with the morphological changes of peripheral blood cells via buffy coat examinatin. The study population included 70 patients clinically diagnosed and pathohistologically confirmed LSCC in addition to 20 healthy controls. According to TNM classification 33(47.1%) patients were in stage I (group I) and 24(34.3%) in...
Clinical Medicine Insights: Endocrinology and Diabetes
A new lancet with an extremely small needle (0.15 mm diameter and 0.75 mm length) mounted on a small pedestal was tested in diabetic patients for blood glucose measurement in a randomized clinical study. A total of 37 diabetic patients were enrolled for the study. A pain scale categorized from...
Background: The aim of this study is to evaluate the prevalence of chronic complications in type 2 diabetic patients in Basrah (Southern Iraq). Methods: This was a longitudinal descriptive study for patients with diabetes registered in Al-Faiha Diabetes and Endocrine Centre in Basrah (Southern Iraq) for the period from...
Clinical Medicine Insights: Gastroenterology
The Role of Adjuvant Therapy in Gastrointestinal Stromal Tumor after Operative Treatment (02/Oct/2009)
The treatment for localized advance gastrointestinal stromal tumor (GIST) is far from ideal. Up to 50% of patient developed post-operative recurrence and died within 5 years. Recently, imatinib was found to significantly improve recurrence-free survival in post-operative patients. The role of adjuvant therapy in high risk GIST patients is discussed....
Fulminant Hepatic Failure Caused by Diffuse Liver Metastases Following Gastrointestinal Stromal Tumor Resection (02/Sep/2009)
Metastatic tumors to the liver resulting in fulminant hepatic failure are a rare occurrence and have not been previously described in patients with gastrointestinal stromal tumor (GIST). A 70 year-old man was referred to hospital with postprandial discomfort. On examination a 19.5 cm large epithelioid GIST of the stomach was...
Clinical Medicine Insights: Geriatrics
HMGCoA-Reductase Inhibitors in Dementia: Benefit or Harm (12/Jun/2009)
Dementia is a syndrome characterized by a decline in cognitive function. Alzheimer’s disease and cerebro-vascular disease are the most common causes of dementia. Many factors (genetic, life style, vascular etc.) appear to play some role in the development of dementia. Statins significantly reduce vascular disease and could reduce cognitive impairment...
Review of Tools and Technologies to Assess Multi-System Functional Impairment and Frailty (20/Mar/2009)
The term ‘frailty’ has often been used—by clinicians and researchers alike—to characterize the most vulnerable and weak amongst the elderly. The treatment and care of this subgroup of older individuals presents the most challenge to clinicians and other health care professionals. Although there is no clear consensus on the issue...
Clinical Medicine Insights: Oncology
Adjuvant Gemcitabine-Oxaliplatin (GEMOX) after Curative Surgery in High-risk Patients with Cholangiocarcinoma (18/Jan/2010)
Background: There is no standard adjuvant chemotherapy to prevent recurrent cholangiocarcinoma (CCA), a rare cancer with poor prognosis. We assessed the efficacy and safety of GEMOX on intrahepatic and hilar CCA with high-risk factors after curative surgery. Patients and Methods: Twenty two patients (mean age: 57 years old) with CCA received 6 cycles of GEMOX: gemcitabine 1,000 mg/m² on day 1 and oxaliplatin 85 mg/m² on day 2, q3w after a curative surgery. Results: All patients completed...
Adjuvant Chemotherapy for Patients with Stage III Colon Cancer: Results from a CDC-NPCR Patterns of Care Study (24/Nov/2009)
Objective: To evaluate adjuvant chemotherapy use for Stage III colon cancer. Methods: This analysis included 973 patients with surgically treated stage III colon cancer. Socioeconomic information from the 2000 census was linked to patients’ residential census tracts. Vital status through 12/31/02 was obtained from medical records and linkage to state vital...
Clinical Medicine Insights: Pathology
Adenomatoid Tumor of Testis (09/Sep/2009)
Adenomatoid tumors are responsible for 30% of all paratesticular masses. These are usually asymptomatic, slow growing masses. They are benign tumors comprising of cords and tubules of cuboidal to columnar cells with vacuolated cytoplasm and fibrous stroma. They are considered to be of mesothelial origin supported by histochemical studies and...
Expression of Placental Neurotrophin-3 (NT-3) in Physiological Pregnancy, Preeclampsia and Chorioamnionitis (11/Jun/2009)
Neurotrophic factors are a group of proteins that act as paracrine and autocrine growth factors. They are involved in the regulation of morphogenesis and development of several tissues. The present study aims to evaluate, for the first time, the expression of Neurotrophin-3 in the human placenta during normal pregnancy and in preeclampsia and chorioamnionitis. Neurotrophin-3 mRNA, assessed by RT-PCR analysis in six term placentas, were observed in all the specimens examined. Neurotrophin-3 protein expression and...
Clinical Medicine Insights: Pediatrics
Background: Infants with neonatal hydronephrosis and a normal voiding cystourethrogram (VCUG) are presumed to have ureteropelvic junction obstruction (UPJO). There is little current information about the natural history of children with hydronephrosis or clinical factors that predict resolution of the radiological abnormality. Objective: To determine the time course until spontaneous resolution...
Background: Indians are suspected to have higher body fat percent at a given body mass index (BMI) than their western counterparts. Objective: To estimate percent body fat in apparently healthy Indian children and adolescents by dual-energy X-ray absorptiometry (DXA) and explore linkages of BMI with body fat percent for better health...
Clinical Medicine Insights: Psychiatry
Neurobiological Pathways Between Chronic Stress and Depression: Dysregulated Adaptive Mechanisms? (08/Dec/2009)
Stress-related diseases have been predicted to become major contributors to the Global Disease Burden within the next 20 years. Of these, depression is one of the principal identifiable sources of concern for public mental health, and has been hypothesized to be an outcome of prolonged stress. Examination of the hyper-responsiveness...
Anthroposophic Therapy for Anxiety Disorders: A Two-year Prospective Cohort Study in Routine Outpatient Settings (10/Jun/2009)
Background and Methods: Anthroposophic treatment for anxiety disorders includes special artistic and physical therapies and special medications. We conducted a prospective cohort study of 64 consecutive adult outpatients starting anthroposophic treatment for anxiety disorders under routine conditions. Main outcomes were Anxiety Severity (physician and patient ratings 0–10), Self-rating Anxiety Scale...
Clinical Medicine Insights: Reproductive Health
A Study of Gonadal Arteries in 30 Adult Human Cadavers (09/Feb/2010)
The gonadal arteries normally arise from the abdominal aorta. There are reports about the variant origin of these arteries. In the present study, we investigated the origin and course of the gonadal arteries and clinical implications of variant gonadal arteries are discussed. Out of 60 dissections, in 55 cases the...
Objective: To explore the relationship between coping mechanisms and suicidal ideations among women who experience symptoms of postpartum depression. Design: This exploratory descriptive study used secondary data from a study of women who experienced symptoms of postpartum depression. Participants: Convenience and purposive sampling were used to obtain the community sample of...
Clinical Medicine Insights: Therapeutics
Dalbavancin is an intravenous semisynthetic lipoglycopeptide which has demonstrated potent in vitro activity again most clinically significant Gram-positive pathogens such as methicillin-resistant Staphylococcus aureus, vancomycin-intermediate Staphylococcus aureus, and some vancomycin-resistant Enterococci. The long half-life of dalbavancin allows for once weekly dosing. In published clinical trials, a dose on day 1...
Morphine or other strong opioids (fentanyl, oxycodone, hydromorphone, buprenorphine) are usually administered in patients with severe cancer and chronic non-malignant pain. However, when these analgesics are ineffective in terms of analgesia or induce intractable adverse effects, a switch to methadone might prove beneficial. Consequently methadone is used in opioid rotation...
Clinical Medicine Insights: Trauma and Intensive Medicine
Radiographic Outcome of Unstable Distal Radial Fracture Treated by Closed Reduction and Pin in Plaster (03/Jun/2009)
Background: There is controversy about the appropriate treatment for severely displaced and unstable comminuted fracture of distal radius (type C of AO or OTA classification). Recently, there has been an increase in the number of predilection for surgical management of this fracture. Aim: To determine the radiographic outcome in type C...
Risk for Repeat Emergency Department Visits for Violent Injuries in Youth Firearm Victims (12/Dec/2008)
Objective: To identify significant risk factors associated with repeat emergency department (ED). Visits for violent injuries in youth fi rearm victims. Methods: The study subjects of this retrospective cohort study were fi rearm victims aged 18 and younger presenting to a Pediatric Emergency Department/Trauma Center at Children’s Hospital of Wisconsin...
Clinical Medicine Insights: Urology
Background: Ureteral catheters are valuable indispensable devices may readily acquire biofilms on the inner or outer surfaces. This study evaluated the efficacies of ureteral catheters impregnated with ciprofloxacin, N-acetylcysteine each alone and in combination on microbial adherence. Methods: Antimicrobial durability of ureteral catheters coated, through instant dip method, with ciprofloxacin were...
Emerging Risk Factors for Urologic Diseases (29/Aug/2008)
Modern medicine has brought us many miracle cures. In the 21st century, especially, we are blessed with increasingly powerful disease combating tools, such as functional genomics, proteomics and stem cells. Decades of medical and pharmaceutical research have produced thousands of medicines that allow us to treat and prevent diseases better...
Clinical Medicine Insights: Women's Health
Chronic Pain of the Vulva without Dermatologic Manifestations: Distinguishing Among a Spectrum of Clinical Disorders (28/Jan/2010)
The causes of chronic vulvar pain are many and when not accompanied by obvious physical signs they are difficult to unravel. Many common vulvar dermatoses can manifest without obvious erythema or mucocutaneous lesions, as can some less common disorders of both infectious and allergic origin. In addition localized and generalized...
Inadequate patient handoffs have been an area of focus for patient safety improvement. Insufficient communication and risks or “shortcuts” taken by staff members during handoffs could negatively affect the safety of patients in a department of obstetrics and gynecology. Other factors that contribute to inadequate handoffs are the caregiver feeling...
Health Services Insights
Review of Omega-3 Fatty Acids for the Treatment of Attention Deficit/Hyperactivity Disorder (24/Nov/2009)
Objective: To review the efficacy of omega-3 fatty acids in the treatment of attention deficit/hyperactivity disorder (ADHD). Data Sources: Literature was accessed via MEDLINE (1950–February 2009) and International Pharmaceutical Abstracts (1960–2009) using the medical subject heading terms omega-3 fatty acids and attention deficit disorder with hyperactivity. Additional references were found by...
Introduction: Levels of utilization of health services vary socially and geographically. Differences in the rates of usage are also associated with geographical aspects of health care systems. The purpose of this study was to capture spatial variations in hospital health services utilization in the elderly population in Hong Kong, a...
Healthy Aging & Clinical Care in the Elderly
Introductory Editorial by Dr David Simar, School of Medical Sciences, University of New South Wales, Sydney NSW 2052, Australia.
Integrative Medicine Insights
Today’s medicine is in the midst of an undeniable crisis. Calls to reform healthcare are in the forefront of economic and political discussions worldwide. Economic pressures reduce the amount of time physicians can spend with patients contributing to burnout among medical staff and endangering the patient iatrogenically. Politicians are getting...
Christine Patterson1 and Heather Arthur21School of Nursing Faculty of Health Sciences McMaster University, Hamilton, Ontario, Canada. 2Cardiovascular Nursing Research Faculty of Health Sciences School of Nursing McMaster University, Hamilton, Ontario, Canada.AbstractLimited information exists on how adolescents decide to use complementary/alternative medicine (CAM). There are also no instruments specific to CAM,...
International Journal of Pain
Introductory Editorial (International Journal of Pain) (26/Aug/2008)
Introductory Editorial by Dr David A. Fishbain, Professor of Psychiatry and Adjunct Professor Neurological Surgery and Anesthesiology, Miller School of Medicine at the University of Miami.
Lipid Insights
Rita K. Upmacis Center of Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065. Abstract Atherosclerosis, a disease characterized by plaque formation in the arterial wall that can lead to heart attack and stroke, is a principal...
C. elegans: A Model for Understanding Lipid Accumulation (13/Oct/2008)
Ida C. Elle, Louise C.B. Olsen, Mai-Britt Mosbech, Steven V. Rødkær, Dennis Pultz, Sanne G. Boelt, Julius Fredens, Pernille Sørensen and Nils Joakim Færgeman Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark. Abstract Regulation and coordination of lipid metabolism involve...
Medical Equipment Insights
The Nokia Wrist–Attached Sensor Platform (NWSP) was developed at the Nokia Research Center during the NUADU project to facilitate research and demonstrations of use cases of wearable wireless sensors. A wrist–worn pedometer application was implemented as one of the demonstrations of the capabilities of the platform. In this paper the...
Single port transumbilical laparoscopic surgery (LESS, SILS, ENOTES) is a technique which has recently emerged with a view to improving the cosmesis following minimal access surgery, aiming to achieve ‘scarless’ surgery. This rapidly progressing technique is facilitated by developments in port and instrument technology, allowing surgeons to perform a wider...
Nutrition and Metabolic Insights
Decreased Serum Cu/Zn SOD in Children with Autism (14/Jan/2010)
Aim: To assess serum Cu/Zn SOD (Superoxide Dismutase) concentration in autistic children and evaluate its possible relationship to GI Symptoms. Subjects and Methods: Serum from 50 autistic children (31 with chronic digestive disease (most with ileo-colonic lymphoid nodular hyperplasia (LNH) and inflammation of the colorectum, small bowel and/or stomach) and 19...
Cathepsin Y Expression is Up-Regulated in Liver and Spleen of the Rats Growing Under a Low Protein Diet (04/May/2009)
Background/Aims: We have previously isolated a novel lysosomal cysteine protease, cathepsin Y, which produces a kinin-potenciating octapeptide from rat plasma. The present study aimed to elucidate the influence of protein-restriction on cathepsin Y mRNA expression in tissues of growing rat. Methods: Weaning rats were fed either 20% casein (normal-protein, NP)...
Open Journal of Cardiovascular Surgery
Triple Vessel Coronary Artery Bypass Grafting in a 14-year-old Child with Familial Hypercholesterolemia-A Rare Case Report (13/Jan/2010)
Familial hypercholesterolemia is a genetic disorder caused by a mutation in the low density lipoprotein (LDL) receptor gene. The homozygous type of the disease is rare and causes tendon xanthomas and coronary artery disease during the early years of life. Premature coronary artery occlusive disease in familial homozygous hypercholesterolemia might...
Doty’s Method (Two Sinus Reconstructions) of Supravalvular Aortic Stenosis in Williams’s Syndrome (24/Nov/2009)
We experienced a successful surgical Williams’s syndrome case of extended aortoplasty by means of Doty’s method (two sinus reconstructions) for congenital supravalvular aortic stenosis. Case was 29-year-old woman, who had no complaint except heart murmur and dyspnea. The retrograde aortography and Digital Subtraction Angiography (DSA) demonstrated localized stenosis just above...
Ophthalmology and Eye Diseases
Spectral Domain OCT Documented Resolution of Pseudophakic Cystoid Macular Edema after Intravitreal Triamcinolone (03/Feb/2010)
Cystoid macular edema (CME) is an important cause of visual loss after cataract surgery. Treatment is usually with topical anti-inflammatory agents, with anti-vascular endothelial growth factor agents and steroids used intravitreally in resistant cases. Even though time-domain Stratus OCT can quantify the macular thickness, it cannot prognosticate visual outcomes due...
Stratification of Antigen-presenting Cells within the Normal Cornea (25/Nov/2009)
The composition and location of professional antigen presenting cells (APC) varies in different mucosal surfaces. The cornea, long considered an immune-privileged tissue devoid of APCs, is now known to host a heterogeneous network of bone marrow-derived cells. Here, we utilized transgenic mice that express enhanced green fluorescent protein (EGFP) from the CD11c promoter (pCD11c) in conjunction with immunohistochemical staining to demonstrate an interesting stratification of APCs within non-inflamed murine corneas. pCD11c+ dendritic cells (DCs)...
Palliative Care: Research and Treatment
Preliminary Report of a Pilot Tele-Health Palliative Care and Bioethics Program for Residents in Skilled Nursing Facilities (08/Dec/2009)
Currently about 25% of Americans die in nursing homes, many with poorly controlled pain and other symptoms, with minimal provisions for psychosocial support. New models are necessary to lessen structural and process barriers to give effective end-of-life care in nursing homes. Objectives: 1) To extend hospital-based Bioethics Consultation Services (BCS) and...
Revisiting the Use of Percutaneous Endoscopic Gastrostomy Tubes in Patients with Advanced Dementia (13/Jul/2009)
Mr. Smith is an 85-year-old nursing home patient who has suffered from dementia for the past eight years. He has been bed bound and uncommunicative for the last six months. He was admitted with aspiration pneumonia three times in the past year. Over the last few months he has lost...


