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Publication Date: 26 Mar 2008
Journal: Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine
It is common knowledge that asbestos exposure causes asbestos-related diseases such as asbestosis, lung cancer and malignant mesothelioma (MM) not only in people who have handled asbestos in the work environment, but also in residents living near factories that handle asbestos. These facts have been an enormous medical and social problem in Japan since the summer of 2005. We focused on the immunological effects of asbestos and silica on the human immune system. In this brief review, we present immunological changes in patients with MM and outline their experimental detection. For example, there is over-expression of bcl-2 in CD4+ peripheral T-cells, high plasma concentrations of interleukin (IL)-10 and transforming growth factor (TGF)-ß, and multiple over-representation of T cell receptor (TcR)-Vß in peripheral CD3+ T-cells found in MM patients. We also detail an experimental long-term exposure T-cell model. Analysis of the immunological effects of asbestos may help our understanding of the biological effects of asbestos.
This is the first time we published an article in Substance Abuse: Research and Treatment, and we were pleased to find that the publishing staff were extremely helpful in guiding our submission through all the hoops. More important they answered our concerns without delay and where necessary made changes in the page proofs in accord with our wishes. I have published upwards of 80 or 90 articles, chapters and edited volumes, and I have never worked with a publishing staff who were as responsive as the staff of SART. At first, we wondered how fast a team of editors half a globe away were going to receive our edits and act on them – the answer was “immediately.” They must never sleep down under.Dr Jan Howard (Senior Scientific Advisor, Westat Corporation, Rockville, Maryland) What Your Colleagues Say
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