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Clinical Medicine Insights: Endocrinology and Diabetes

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Insulin Degludec, The New Generation Basal Insulin or Just another Basal Insulin?

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Publication Date: 11 Apr 2012

Type: Consise Review

Journal: Clinical Medicine Insights: Endocrinology and Diabetes

Citation: Clinical Medicine Insights: Endocrinology and Diabetes 2012:5 31-37

doi: 10.4137/CMED.S9494

Abstract

The advances in recombinant DNA technology have led to an improvement in the properties of currently available long-acting insulin analogs. Insulin degludec, a new generation ultra-long-acting basal insulin, currently in phase 3 clinical trials, has a promising future in clinical use. When compared to its rival basal insulin analogs, a longer duration of action and lower incidence of hypoglycemic events in both type 1 and type 2 diabetic patients has been demonstrated.1,2 Its unique mechanism of action is based on multihexamer formation after subcutaneous injection. This reportedly allows for less pharmacodynamic variability and within-subject variability than currently available insulin analogs, and a duration of action that is over 24 hours.3 The lack of proof of carcinogenicity with insulin degludec is yet another factor that would be taken into consideration when choosing the optimal basal insulin for a diabetic individual.4 A formulation of insulin degludec with insulin aspart, Insulin degludec 70%/aspart 30%, may permit improved flexibly of dosing without compromising glycemic control or safety.5


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My experience with Libertas Academica was excellent. The review process was smooth and speedy. After publishing, I received a kind and favorable response from a reader. I have never experienced such a comment after my publications to orthodox journals.
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