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Publication Date: 09 Feb 2008
Journal: Clinical Medicine Insights: Blood Disorders
Citation: Clinical Medicine: Blood Disorders 2008:1 21-25
Hôpital Saint Louis AP-HP, services d’hématologie et radiothérapie, Paris, France. ²Hôpital Notre Dame, Charleroi, Belgique.
Abstract
In patients with Hodgkin lymphoma (HL) a continued improvement in outcome with a high cure rate is observed but with an increased treatment-induced late effects. We report the long-term results from 188 (stage I to IIIA) patients treated during the period 1985–94 with 3 courses of ABVD-like chemotherapy and subtotal nodal radiotherapy. 10 year overall survival is of 88% and no secondary leukaemia was observed. The main long term toxicity was cardiac, mainly related to a mediastinal dose of 45 Grays in patients with partial remission. New strategies are aiming to reduce the mediastinal dose at 30 Grays after chemotherapy-induced complete remission.
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