Clinical Medicine Reviews in Therapeutics

Lorcaserin and the Role of 5-HT2C Agonism in the Treatment of Obesity

Submit a Paper

Clinical Medicine Reviews in Therapeutics 2011:3 347-354


Published on 19 Sep 2011

DOI: 10.4137/CMRT.S5768

Further metadata provided in PDF

Sign up for email alerts to receive notifications of new articles published in Clinical Medicine Reviews in Therapeutics


The serotonin (5-HT) system is implicated in the control of human appetite expression. However, previous serotonergic approaches to obesity, d-fenfluramine and sibutramine, were withdrawn over issues of safety. Selectively targeting hypothalamic 5-HT2C receptors should reduce the side effects produced by previous treatment. Lorcaserin is the first of a new generation of highly selective 5-HT2C agonists to pass through clinical development. Data is limited but the drug produces significant reductions in energy intake. These appear small compared to those reportedly produced by sibutramine and there is little evidence to indicate behavioural specificity or a clear satiety effect. However, Lorcaserin produces significant placebo-subtracted weight loss over two years of treatment which may be greater than current treatments such as the lipase inhibitor orlistat. Drugs that strengthen satiety may help individuals resist the urge to over-consume and maintain the reduction in energy intake required for successful weight control. However, for a number of patients Lorcaserin proved to be ineffective. For a centrally acting agent the drug's effect on appetite and behaviour remain poorly characterised. In summary, Lorcaserin produces statistically significant effects on energy intake, but the clinical significance of these findings is still debatable. Furthermore, the history of serotonin drugs indicates caution is warranted.



BibTex citation   (BIBDESK, LATEX)

What Your Colleagues Say About Libertas Academica
The publication of our paper in Bioinformatics and Biology Insights was highly professional and very pleasant on all levels: the guidelines for authors are concise, the online submission system is user-friendly, the comments from the reviewers were insightful and improved our paper, and the preparation of the manuscript for publication was efficient. I particularly liked the fast feedback from the staff on the state of the submission and review process.
Professor Werner Braun (Department of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, Texas, USA)
More Testimonials

Quick Links

New article and journal news notification services