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Clinical Medicine Insights: Blood Disorders

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Occurrence of Acute Myeloid Leukemia in Young Pregnant Women

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Publication Date: 20 Jun 2008

Journal: Clinical Medicine Insights: Blood Disorders

Citation: Clinical Medicine: Blood Disorders 2008:1 27-31

Juliane Menezes1, Mariana Emerenciano1, Flávia Pimenta2, Gilson Guedes Filho5, Isis Q. Magalhães3, Mariana Sant’Ana1, Marina Lipkin Vasquez4, Ilana Zalcberg Renault4 and Maria S. Pombo-de-Oliveira1

1Programa de Hematologia e Oncologia Pediátricos, Centro de Pesquisa, Instituto Nacional de Câncer, Rio de Janeiro, RJ, Brazil. 2Departamento Medicina Interna, Disciplina Hematologia UFPB, João Pessoa, PB, Brazil. 3Departamento de Hematologia / Oncologia Pediátrica SES-DF, Brasília, DF, Brazil. 4Centro de Transplante de Medula Óssea—CEMO—Instituto Nacional de Câncer, Rio de Janeiro, RJ, Brazil. 5Departamento de Hematologia Hospital Universitário, João Pessoa, PB, Brazil.

Abstract

Although acute leukaemia is rare in pregnancy its importance lies in its life-threatening potential, both to the child and the mother. The possibility of vertical transmission of leukemic cells increases the attention devoted to these patients and their offspring. Three cases of pregnant young women (15–17 years of age) with AML are presented. This series of cases is the first report where gene abnormalities such as ITD mutations of the FLT3 gene and AML1/ETO fusion genes were screened in pregnant AML patients and their babies, so far. Unfortunately, very poor outcomes have been associated to similar cases described in literature, and the same was true to the patients described herein. Although very speculative, we think that the timing and possible similar exposures would be involved in all cases.


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