1Programa de Hematologia e Oncologia Pediátricos, Centro de Pesquisa, Instituto Nacional de Câncer, Rio de Janeiro, RJ, Brazil. 2Departamento Medicina Interna, Disciplina Hematologia UFPB, João Pessoa, PB, Brazil. 3Departamento de Hematologia / Oncologia Pediátrica SES-DF, Brasília, DF, Brazil. 4Centro de Transplante de Medula Óssea—CEMO—Instituto Nacional de Câncer, Rio de Janeiro, RJ, Brazil. 5Departamento de Hematologia Hospital Universitário, João Pessoa, PB, Brazil.
Although acute leukaemia is rare in pregnancy its importance lies in its life-threatening potential, both to the child and the mother. The possibility of vertical transmission of leukemic cells increases the attention devoted to these patients and their offspring. Three cases of pregnant young women (15–17 years of age) with AML are presented. This series of cases is the first report where gene abnormalities such as ITD mutations of the FLT3 gene and AML1/ETO fusion genes were screened in pregnant AML patients and their babies, so far. Unfortunately, very poor outcomes have been associated to similar cases described in literature, and the same was true to the patients described herein. Although very speculative, we think that the timing and possible similar exposures would be involved in all cases.
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Compared with other journals we considered for publishing, Cancer Informatics provided extremely rapid but quality turnaround from draft submission to a flawlessly typeset final publication. Moreover, sharing the article is now as easy as sharing a link with no subscriptions required, and additional code and data files are equally accessible, supporting reproducible research. Because it has published many of our references we feel confident that our target readership must follow the journal. This is further ...