Close
Help




JOURNAL

Translational Oncogenomics

76,622 Journal Article Views | Journal Analytics

Oncogene Mutation Survey in MPNST Cell Lines Enhances the Dominant Role of Hyperactive Ras in NF1 Associated Pro-Survival and Malignancy

Submit a Paper



Publication Date: 18 Jan 2012

Type: Short Report

Journal: Translational Oncogenomics

Citation: Translational Oncogenomics 2012:5 1-7

doi: 10.4137/TOG.S8830

Abstract

Malignant peripheral nerve sheath tumors (MPNST) are a type of soft tissue sarcoma that can be associated with germline mutations in Neurofibromatosis type 1 (NF1) or may occur sporadically. Although the etiology of MPNST is poorly understood, it is clear that a loss of function of the NF1 gene, encoding a Ras-GAP, is an important factor in the tumorigenesis of the inherited form of MPNST. Tumor latency in NF1 patients suggests that additional mutational events are probably required for malignancy. In order to define oncogene mutations associated with 5 MPNST cell lines, we assayed the 238 most frequent mutations in 19 commonly activated oncogenes using mass spectroscopy-based analysis. All 238 mutation sites in the assayed oncogenes were determined to harbor only wild-type sequences. These data suggest that hyperactive Ras resulting from the loss function of neurofibromin may be sufficient to set up the direction of malignant transformation of Schwann cells to MPNST.


Downloads

PDF  (602.16 KB PDF FORMAT)

RIS citation   (ENDNOTE, REFERENCE MANAGER, PROCITE, REFWORKS)

BibTex citation   (BIBDESK, LATEX)

XML






What Your Colleagues Say About Translational Oncogenomics
As an author of a review published in Translational Oncogenomics, I was impressed by the prompt processing and speed of publication. The entire submission, review and publication process was easy, quick and pleasant. The comments from reviewers and associate editor were high quality, scientifically deep and objective. It was a great pleasure to cooperate with such qualified and friendly team. I highly recommend publication in Libertas Academica journals.
Dr Joseph Zaretsky (Tel Aviv University, Israel)
More Testimonials

Quick Links


New article and journal news notification services