Close
Help




JOURNAL

Clinical Medicine Insights: Oncology

575,996 Journal Article Views | Journal Analytics

Pazopanib for the Treatment of Patients with Advanced Renal Cell Carcinoma

Submit a Paper



Publication Date: 01 Oct 2010

Type: Review

Journal: Clinical Medicine Insights: Oncology

Citation: Clinical Medicine Insights: Oncology 2010:4 95-105

doi: 10.4137/CMO.S4088

Abstract

Dramatic advances in the care of patients with advanced renal cell carcinoma have occurred over the last ten years, including insights into the molecular pathogenesis of this disease, that have now been translated into paradigm-changing therapeutic strategies. Elucidating the importance of signaling cascades related to angiogenesis is notable among these achievements. Pazopanib is a novel small molecule tyrosine kinase inhibitor that targets VEGFR-1, -2, and -3; PDGFR-α, PDGFR-β; and c-kit tyrosine kinases. This agent exhibits a distinct pharmacokinetic profile as well as toxicity profile compared to other agents in the class of VEGF signaling pathway inhibitors. This review will discuss the scientific rationale for the development of pazopanib, as well as preclinical and clinical trials that led to approval of pazopanib for patients with advanced renal cell carcinoma. The most recent information, including data from 2010 national meeting of the American Society of Clinical Oncology, and the design of ongoing Phase III trials, will be discussed. Finally, an algorithm utilizing Level I evidence for the treatment of patients with this disease will be proposed.


Downloads

PDF  (584.08 KB PDF FORMAT)

RIS citation   (ENDNOTE, REFERENCE MANAGER, PROCITE, REFWORKS)

BibTex citation   (BIBDESK, LATEX)

XML






What Your Colleagues Say About Clinical Medicine Insights: Oncology
We have had a fantastic and unprecedented experience publishing our paper in Clinical Medicine Insights: Oncology.  The process of submitting and correcting the proofs were simple, quick, and smooth.  We appreciated the clarity and easiness of instructions and your fast responses to our emails. Great work.  Keep it up.
Dr Sabri Sanabani (Hemocentro de São Paulo, Brazil)
More Testimonials

Quick Links


New article and journal news notification services