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Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine

Pharmacotherapies for COPD

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Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine 2013:7 17-34

Review

Published on 25 Apr 2013

DOI: 10.4137/CCRPM.S7211


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Abstract

This review article summarizes the main treatments for chronic obstructive pulmonary disease, their mechanisms, and the key evidence from trials supporting their use. Drug classes covered were short acting beta agonists (SABA), short acting muscarinic antagonists (SAMA), long acting beta agonists (LABA), long acting antimuscarinics (LAMA), inhaled corticosteroids (ICS), LABA/ICS combinations, specific phosphodiesterase (PDE4) inhibitors, non-specific PDE inhibitors, mucolytics, and oxygen. Non-specific therapies, such as opiates for relief of dyspnoea and therapies for smoking cessation, are also covered briefly. For each class of drug, mechanisms of action are described, key clinical trial results are reported, and available agents compared. Finally, the place of each drug in therapy is compared between current worldwide guidelines.



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