Published on 25 Apr 2013
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This review article summarizes the main treatments for chronic obstructive pulmonary disease, their mechanisms, and the key evidence from trials supporting their use. Drug classes covered were short acting beta agonists (SABA), short acting muscarinic antagonists (SAMA), long acting beta agonists (LABA), long acting antimuscarinics (LAMA), inhaled corticosteroids (ICS), LABA/ICS combinations, specific phosphodiesterase (PDE4) inhibitors, non-specific PDE inhibitors, mucolytics, and oxygen. Non-specific therapies, such as opiates for relief of dyspnoea and therapies for smoking cessation, are also covered briefly. For each class of drug, mechanisms of action are described, key clinical trial results are reported, and available agents compared. Finally, the place of each drug in therapy is compared between current worldwide guidelines.
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This is the first time I have published in Genetics and Epigenetics and it was easy and efficient. The peer reviews took less time than I supposed they would. The remarks were appropriate and made by qualified peer reviewers. All paths from submission to publication were easy, rapid and understandable. I was impressed by the professionalism and punctuality of peer reviewers, Editor in Chief and all staff members of this journal. Keep up the good ...