Close
Help




JOURNAL

Clinical Medicine Insights: Therapeutics

1,374,372 Journal Article Views | Journal Analytics

Pregabalin and Fibromyalgia Syndrome: A Treatment Option

Submit a Paper



Publication Date: 15 Jul 2009

Type: Review

Journal: Clinical Medicine Insights: Therapeutics

Citation: Clinical Medicine: Therapeutics 2009:1 809-824

Abstract

Fibromyalgia (FM) is a chronic complex pain disorder that is multidimensional and exhibits heterogeneity requiring a long-term multidisciplinary approach to management. Many of the drugs used in the treatment of FM have been focused to the management of single symptoms; often such drugs fail to demonstrate acceptable efficacy in the majority of the patient population. Pregabalin is an α2-δ ligand that regulates the release and postsynaptic actions of neurotransmitters related to analgesic, anticonvulsant and anxiolytic properties. In randomized, double-blind, placebo-controlled studies, pregabalin has demonstrated an improvement in pain, sleep and fatigue symptoms associated with FM, as well as offering an improvement in parameters related to quality of life. Although the positive outcomes obtained with pregabalin support its use as an option for the management of FM, the efficacy was restricted to a selected patient population outside of the usual care setting. Current data do not allow an explanation where there are any limitations of pregabalin as a treatment of patients with FM, as to whether this is a deficiency of the drug or the process of assessment (e.g. assessment tools of FM, clinical trial design).


Downloads

RIS citation   (ENDNOTE, REFERENCE MANAGER, PROCITE, REFWORKS)

BibTex citation   (BIBDESK, LATEX)






What Your Colleagues Say About Clinical Medicine Insights: Therapeutics
I was pleased to serve as a peer reviewer for Clinical Medicine Insights: Therapeutics.  Its scope will hopefully blur some of the lines that still exist between clinical and basic science.  The diligence of the editorial staff ensures the review process is fair, fast and very well-organized.  I highly recommend potential authors and reviewers to submit to and review for this journal.
Dr Sharilyn Almodovar (University of Colorado Denver, Aurora, CO, USA)
More Testimonials

Quick Links


Follow Us We make it easy to find new research papers.