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Abstract A majority of extant life forms require O2 to survive and thrive. Oxidation is inevitably one of the most active cellular processes and one constant challenge that living organisms must face. Generation of oxidants including reactive oxygen species is a natural consequence of cellular metabolism of all biological systems during normal life cycle under different environments. These oxidants oxidize many biological macromolecules such as proteins and affect their functions. Oxidation of specific amino acids in proteins may cause damage to protein structure and impair function, or may also activate protein activities and promote cellular metabolism. As an example, the reversible oxidation of cysteine and methionine residues has a profound impact on protein function and cellular process. A recent study that examines the effect of Met oxidation on Ser phosphorylation in a mitochondrial enzyme, pyruvate dehydrogenase, provides another demonstration that protein oxidation is an important regulatory mechanism for organisms to deal with developmental and environmental challenges throughout life processes.
I was pleased to serve as a peer reviewer for Clinical Medicine Insights: Therapeutics. Its scope will hopefully blur some of the lines that still exist between clinical and basic science. The diligence of the editorial staff ensures the review process is fair, fast and very well-organized. I highly recommend potential authors and reviewers to submit to and review for this journal.Dr Sharilyn Almodovar (University of Colorado Denver, Aurora, CO, USA) What our authors say
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