Close
Help




JOURNAL

Clinical Medicine Insights: Endocrinology and Diabetes

Saxagliptin: A Selective DPP-4 Inhibitor for the Treatment of Type 2 Diabetes Mellitus

Submit a Paper


Clinical Medicine Insights: Endocrinology and Diabetes 2011:4 1-12

Review

Published on 12 Jan 2011

DOI: 10.4137/CMED.S5114


Further metadata provided in PDF



Sign up for email alerts to receive notifications of new articles published in Clinical Medicine Insights: Endocrinology and Diabetes

Abstract

The prevalence of type 2 diabetes mellitus is high and growing rapidly. Suboptimal glycemic control provides opportunities for new treatment options to improve the morbidity and mortality of this progressive disease. Saxagliptin, a selective DPP-4 inhibitor, increases endogenous incretin levels and incretin acitivty. In controlled clinical trials saxagliptin reduces both fasting and postprandial glucose and works in monotherapy and in combination with metformin, TZDs and sulfonylureas. Saxagliptin has a very favourable side effect profile and may have other beneficial non-glycemic effects. The authors review the current available evidence for the safety, efficacy and saxagliptin's place in therapy for type 2 diabetes mellitus. As understanding of the incretin hormones (GLP-1, GIP) expand we may see additional important non-glycemic effects that may affect the chronic management of type 2 diabetes mellitus.



Downloads

PDF  (582.32 KB PDF FORMAT)

RIS citation   (ENDNOTE, REFERENCE MANAGER, PROCITE, REFWORKS)

BibTex citation   (BIBDESK, LATEX)

XML




What Your Colleagues Say About Clinical Medicine Insights: Endocrinology and Diabetes
I would like to congratulate Clinical Medicine Insights: Endocrinology and Diabetes for the professional way it manages the entire publication process.  I am certain it will have a bright future, and reach top positions among endocrine and metabolic journals.
Dr Francisco Bandeira (University of Pernambuco Medical School, Recife, Brazil)
More Testimonials

Quick Links


New article and journal news notification services