DHHS/NIH/National Cancer Institute/Division of Cancer Prevention, EPN, 6130 Executive Blvd, Bethesda, MD 20892, U.S.A.
In this paper, we outline the status quo and approaches to further development of the systems biology concepts with focus on applications in cancer prevention science. We discuss the biological aspects of cancer research that are of primary importance in cancer prevention, motivations for their mathematical modeling and some recent advances in computational oncology. We also make an attempt to outline in big conceptual terms the contours of future work aimed at creation of large-scale computational and informational infrastructure for using as a routine tool in cancer prevention science and decision making.
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The reviewing and editorial management of our paper was timely, thorough, and systematic. In particular the reviewers' comments resulted in a paper significantly more robust than the first version.