Close
Help
Need Help?





JOURNAL

International Journal of Tryptophan Research

258,083 Journal Article Views | Journal Analytics

The Kynurenine Pathway in Stem Cell Biology

Submit a Paper



Publication Date: 15 Sep 2013

Type: Review

Journal: International Journal of Tryptophan Research

Citation: International Journal of Tryptophan Research 2013:6 57-66

doi: 10.4137/IJTR.S12626

Abstract

The kynurenine pathway (KP) is the main catabolic pathway of the essential amino acid tryptophan. The KP has been identified to play a critical role in regulating immune responses in a variety of experimental settings. It is also known to be involved in several neuroinflammatory diseases including Huntington’s disease, amyotrophic lateral sclerosis, and Alzheimer’s disease. This review considers the current understanding of the role of the KP in stem cell biology. Both of these fundamental areas of cell biology have independently been the focus of a burgeoning research interest in recent years. A systematic review of how the two interact has not yet been conducted. Several inflammatory and infectious diseases in which the KP has been implicated include those for which stem cell therapies are being actively explored at a clinical level. Therefore, it is highly relevant to consider the evidence showing that the KP influences stem cell biology and impacts the functional behavior of progenitor cells.


Downloads

PDF  (516.15 KB PDF FORMAT)

RIS citation   (ENDNOTE, REFERENCE MANAGER, PROCITE, REFWORKS)

BibTex citation   (BIBDESK, LATEX)

XML






What Your Colleagues Say About International Journal of Tryptophan Research
My first experience with Int J Tryptophan Res has been tremendous.  The whole process from submission to publication could not be better had I submitted this work elsewhere.  The editorial staff were most courteous and kept me informed of the progress of the submission step by step. The whole process was run very smoothly and I could simply say that it was a unique and a most enjoyable professional experience having published in IJTR. ...
Professor Abdulla Badawy (University of Wales Institute Cardiff, Wales, UK)
More Testimonials

Quick Links




Follow Us We make it easy to find new research papers.




SUBJECT HUBS
Author Survey Results
author_survey_results
All authors are surveyed after their articles are published. Authors are asked to rate their experience in a variety of areas, and their responses help us to monitor our performance. Presented here are their responses in some key areas. No 'poor' or 'very poor' responses were received; these are represented in the 'other' category.
See Our Results