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JOURNAL

International Journal of Tryptophan Research

The Kynurenine Pathway in Stem Cell Biology

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International Journal of Tryptophan Research 2013:6 57-66

Review

Published on 15 Sep 2013

DOI: 10.4137/IJTR.S12626


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Abstract

The kynurenine pathway (KP) is the main catabolic pathway of the essential amino acid tryptophan. The KP has been identified to play a critical role in regulating immune responses in a variety of experimental settings. It is also known to be involved in several neuroinflammatory diseases including Huntington’s disease, amyotrophic lateral sclerosis, and Alzheimer’s disease. This review considers the current understanding of the role of the KP in stem cell biology. Both of these fundamental areas of cell biology have independently been the focus of a burgeoning research interest in recent years. A systematic review of how the two interact has not yet been conducted. Several inflammatory and infectious diseases in which the KP has been implicated include those for which stem cell therapies are being actively explored at a clinical level. Therefore, it is highly relevant to consider the evidence showing that the KP influences stem cell biology and impacts the functional behavior of progenitor cells.



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What Your Colleagues Say About International Journal of Tryptophan Research
My first experience with Int J Tryptophan Res has been tremendous.  The whole process from submission to publication could not be better had I submitted this work elsewhere.  The editorial staff were most courteous and kept me informed of the progress of the submission step by step. The whole process was run very smoothly and I could simply say that it was a unique and a most enjoyable professional experience having published in IJTR. ...
Professor Abdulla Badawy (University of Wales Institute Cardiff, Wales, UK)
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