Uncertainty Analysis of Drug Concentration in Pharmaceutical Mixtures
Authors: Michalakis Savva
Publication Date: 03 Jun 2008
Analytical Chemistry Insights 2006:1 1-3
Michalakis Savva
Division of Pharmaceutical Sciences, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201.
Abstract
Using a Taylor expansion to first order, a novel method was developed to calculate the uncertainty of drug concentration in pharmaceutical dosage forms. The method allows, in principle, calculation of the maximum potential error in drug concentration in a mixture composed of an infinite number of ingredients that are measured on multiple balances of variable sensitivity requirements.
Categories:
Analytical chemistry
Keywords: uncertainty propagation analysis; powder mixtures; dosage forms; drug compounding
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