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Uncertainty Analysis of Drug Concentration in Pharmaceutical Mixtures

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Publication Date: 03 Jun 2008

Journal: Analytical Chemistry Insights 2006:1 1-3

ACI
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Abstract Michalakis Savva

Division of Pharmaceutical Sciences, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201.

Abstract

Using a Taylor expansion to first order, a novel method was developed to calculate the uncertainty of drug concentration in pharmaceutical dosage forms. The method allows, in principle, calculation of the maximum potential error in drug concentration in a mixture composed of an infinite number of ingredients that are measured on multiple balances of variable sensitivity requirements.


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