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JOURNAL

International Journal of Tryptophan Research


An international, peer reviewed, open access journal that focuses on all subjects related to tryptophan research, including isolation, functionality, interactions, analysis, synthesis and industrial production, as well as supplementation and role in diet, physiology, neurological disorders and immune response.  Also of interest to the journal are related precursors and metabolites such as serotonin, melatonin, niacin, tryptamine, kynurenine, and indoleamine 2,3-dioxygenase.

Editor in Chief: Professor Gilles Guillemin

ISSN: 1178-6469

Processing Speed: High quality, constructive peer review and rapid editorial decision within an average of four weeks.



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Effects of Various Kynurenine Metabolites on Respiratory Parameters of Rat Brain, Liver and Heart Mitochondria
Halina Baran, Katrin Staniek, Melanie Bertignol-Spörr, Martin Attam, Carina Kronsteiner and Berthold Kepplinger
International Journal of Tryptophan Research 2016:9 17-29
Original Research | Published on 17 May 2016



Diet Versus Exercise in Weight Loss and Maintenance: Focus on Tryptophan
Barbara Strasser and Dietmar Fuchs
International Journal of Tryptophan Research 2016:9 9-16
Review | Published on 10 May 2016



Organ Correlation with Tryptophan Metabolism Obtained by Analyses of TDO-KO and QPRT-KO Mice
Katsumi Shibata and Tsutomu Fukuwatari
International Journal of Tryptophan Research 2016:9 1-7
Review | Published on 28 Apr 2016



Chronic Antipsychotic Treatment in the Rat – Effects on Brain Interleukin-8 and Kynurenic Acid
Markus K. Larsson, Lilly Schwieler, Michel Goiny, Sophie Erhardt and Göran Engberg
International Journal of Tryptophan Research 2015:8 49-52
Original Research | Published on 20 Sep 2015



Tryptophan Catabolism in Chronic Viral Infections: Handling Uninvited Guests
Vikram Mehraj and Jean-Pierre Routy
International Journal of Tryptophan Research 2015:8 41-48
Review | Published on 04 Aug 2015



Method for Evaluation of the Requirements of B-group Vitamins Using Tryptophan Metabolites in Human Urine
Katsumi Shibata, Junko Hirose and Tsutomu Fukuwatari
International Journal of Tryptophan Research 2015:8 31-39
Original Research | Published on 19 Apr 2015



Tryptophan-Ethylester, the False (Unveiled) Melatonin Isomer in Red Wine
Marcello Iriti and Ileana Vigentini
International Journal of Tryptophan Research 2015:8 27-29
Short Commentary | Published on 30 Mar 2015



Conversion Percentage of Tryptophan to Nicotinamide is Higher in Rice Protein Diet than in Wheat Protein Diet in Rats
Katsumi Shibata, Tsutomu Fukuwatari and Tomoyo Kawamura
International Journal of Tryptophan Research 2015:8 19-25
Original Research | Published on 05 Mar 2015



The Aryl Hydrocarbon Receptor: A Review of Its Role in the Physiology and Pathology of the Integument and Its Relationship to the Tryptophan Metabolism
Rowland Noakes
International Journal of Tryptophan Research 2015:8 7-18
Review | Published on 10 Feb 2015



Enantiomeric Separation of Monosubstituted Tryptophan Derivatives and Metabolites by HPLC with a Cinchona Alkaloid-Based Zwitterionic Chiral Stationary Phase and Its Application to the Evaluation of the Optical Purity of Synthesized 6-Chloro-L-Tryptophan
Takeshi Fukushima, Anna Sugiura, Ippei Furuta, Sumiko Iwasa, Hideaki Iizuka, Hideaki Ichiba, Mayu Onozato, Hidemasa Hikawa and Yuusaku Yokoyama
International Journal of Tryptophan Research 2015:8 1-5
Original Research | Published on 07 Jan 2015



Mechanisms of the Pellagragenic Effect of Leucine: Stimulation of Hepatic Tryptophan Oxidation by Administration of Branched-Chain Amino Acids to Healthy Human Volunteers and the Role of Plasma Free Tryptophan and Total Kynurenines
Abdulla A-B Badawy, Sarah L. Lake and Donald M. Dougherty
International Journal of Tryptophan Research 2014:7 23-32
Original Research | Published on 04 Dec 2014



Imbalanced Kynurenine Pathway in Schizophrenia
Magdalena E. Kegel, Maria Bhat, Elisabeth Skogh, Martin Samuelsson, Kristina Lundberg, Marja-Liisa Dahl, Carl Sellgren, Lilly Schwieler, Göran Engberg, Ina Schuppe-Koistinen, and Sophie Erhardt
International Journal of Tryptophan Research 2014:7 15-22
Original Research | Published on 16 Sep 2014



Tryptophan and Kynurenic Acid May Produce an Amplified Effect in Central Fatigue Induced by Chronic Sleep Disorder
Masatoshi Yamashita and Takanobu Yamamoto
International Journal of Tryptophan Research 2014:7 9-14
Original Research | Published on 14 May 2014



Kynurenic Acid Levels in Cerebrospinal Fluid from Patients with Alzheimer's Disease or Dementia with Lewy Bodies
Malin Wennström, Henrietta M Nielsen, Funda Orhan, Elisabet Londos, Lennart Minthon and Sophie Erhardt
International Journal of Tryptophan Research 2014:7 1-7
Original Research | Published on 28 Apr 2014



Immunohistochemical Studies of the Kynurenine Pathway in Morphea
Rowland Noakes, Nick Mellick
International Journal of Tryptophan Research 2013:6 97-102
Original Research | Published on 23 Dec 2013



Sustained Elevation of Kynurenic Acid in the Cerebrospinal Fluid of Patients with Herpes Simplex Virus Type 1 Encephalitis
Ann Atlas, Elisabeth Franzen-Röhl, Johan Söderlund, Erik G Jönsson, Martin Samuelsson, Lilly Schwieler, Birgit Sköldenberg and Göran Engberg
International Journal of Tryptophan Research 2013:6 89-96
Original Research | Published on 25 Nov 2013



Big Brains, Meat, Tuberculosis, and the Nicotinamide Switches: Co-Evolutionary Relationships with Modern Repercussions?
Adrian C. Williams and Robin I.M. Dunbar
International Journal of Tryptophan Research 2013:6 73-88
Perspective | Published on 15 Oct 2013



Relationships between Salivary Melatonin Levels, Quality of Sleep, and Stress in Young Japanese Females
Yasuhiro Ito, Tadayuki Iida, Yuumi Yamamura, Mayu Teramura, Yasushi Nakagami, Kaoru Kawai, Yoichi Nagamura and Ryoji Teradaira
International Journal of Tryptophan Research 2013:6 (Suppl. 1) 75-85
Original Research | Published on 10 Oct 2013



Effects of Tranilast on the Urinary Excretion of Kynurenic and Quinolinic Acid Under Conditions of L Tryptophan Loading
Rowland R. Noakes
International Journal of Tryptophan Research 2013:6 67-71
Original Research | Published on 22 Sep 2013



The Kynurenine Pathway in Stem Cell Biology
Simon P. Jones, Gilles J. Guillemin and Bruce J. Brew
International Journal of Tryptophan Research 2013:6 57-66
Review | Published on 15 Sep 2013



Kynurenic Acid in the Digestive System—New Facts, New Challenges
Michal P. Turski, Monika Turska, Piotr Paluszkiewicz, Jolanta Parada-Turska and Gregory F. Oxenkrug
International Journal of Tryptophan Research 2013:6 47-55
Consise Review | Published on 04 Sep 2013



The Tumor-Selective Cytotoxic Agent ß-Lapachone is a Potent Inhibitor of IDO1
Hollie E. Flick, Judith M. LaLonde, William P. Malachowski and Alexander J. Muller
International Journal of Tryptophan Research 2013:6 35-45
Original Research | Published on 19 Aug 2013



L-Tryptophan Metabolism in Pregnant Mice Fed a High L-Tryptophan Diet and the Effect on Maternal, Placental, and Fetal Growth
Ai Tsuji, Chifumi Nakata, Mitsue Sano, Tsutomu Fukuwatari and Katsumi Shibata
International Journal of Tryptophan Research 2013:6 21-33
Original Research | Published on 14 Aug 2013



ISTRY 2013 Special Issue
Gilles J. Guillemin
International Journal of Tryptophan Research 2013:6 (Suppl. 1) 1-2
Editorial | Published on 21 Jul 2013



Nutritional Aspect of Tryptophan Metabolism
Tsutomu Fukuwatari and Katsumi Shibata
International Journal of Tryptophan Research 2013:6 (Suppl. 1) 3-8
Review | Published on 21 Jul 2013



Determination of L-tryptophan and L-kynurenine in Human Serum by using LC-MS after Derivatization with (R)-DBD-PyNCS
Hayato Ohashi, Hideaki Iizuka, Shunsuke Yoshihara, Hayato Otani, Misato Kume, Kiyomi Sadamoto, Hideaki Ichiba and Takeshi Fukushima
International Journal of Tryptophan Research 2013:6 (Suppl. 1) 9-14
Original Research | Published on 21 Jul 2013



Role of NAD+, Oxidative Stress, and Tryptophan Metabolism in Autism Spectrum Disorders
Musthafa Mohamed Essa, Selvaraju Subash, Nady Braidy, Samir Al-Adawi, Chai K Lim, Tamilarasan Manivasagam and Gilles J Guillemin
International Journal of Tryptophan Research 2013:6 (Suppl. 1) 15-28
Review | Published on 21 Jul 2013



Induction of TDO2 and IDO2 in Liver by High-Fat Feeding in Mice: Discrepancies with Human Obesity
Odile Poulain-Godefroy, Elodie Eury, Audrey Leloire, Benjamin Hennart, Gilles J. Guillemin, Delphine Allorge, and Philippe Froguel
International Journal of Tryptophan Research 2013:6 (Suppl. 1) 29-37
Meeting Report | Published on 21 Jul 2013



Kynurenine Pathway Pathologies: do Nicotinamide and Other Pathway Co-Factors have a Therapeutic Role in Reduction of Symptom Severity, Including Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM)
Adele Blankfield
International Journal of Tryptophan Research 2013:6 (Suppl. 1) 39-45
Commentary | Published on 21 Jul 2013



Species and Cell Types Difference in Tryptophan Metabolism
Yuki Murakami and Kuniaki Saito
International Journal of Tryptophan Research 2013:6 (Suppl. 1) 47-54
Review | Published on 21 Jul 2013



Tryptophan-Restriction Diets Help to Maintain L-Tryptophan Homeostasis in Tryptophan 2,3-Dioxygenase Knockout Mice
Akihiro Maeta, Tsutomu Fukuwatari, Hiroshi Funakoshi, Toshikazu Nakamura and Katsumi Shibata
International Journal of Tryptophan Research 2013:6 (Suppl. 1) 55-65
Original Research | Published on 21 Jul 2013



Exploitation of the IDO Pathway in the Therapy of Rheumatoid Arthritis
Richard O. Williams
International Journal of Tryptophan Research 2013:6 (Suppl. 1) 67-73
Review | Published on 21 Jul 2013



Characterization of the Kynurenine Pathway and Quinolinic Acid Production in Macaque Macrophages
Chai K. Lim, Margaret M.C. Yap, Stephen J. Kent, Gabriel Gras, Boubekeur Samah, Jane C. Batten, Robert De Rose, Benjamin Heng, Bruce J. Brew, and Gilles J. Guillemin
International Journal of Tryptophan Research 2013:6 7-19
Original Research | Published on 15 May 2013



Transport of Kynurenic Acid by Rat Organic Anion Transporters rOAT1 and rOAT3: Species Difference between Human and Rat in OAT1
Yuichi Uwai, Hiroaki Hara and Kikuo Iwamoto
International Journal of Tryptophan Research 2013:6 1-6
Original Research | Published on 17 Feb 2013



Kynurenic Acid Metabolism in Various Types of Brain Pathology in HIV-1 Infected Patients
H. Baran, J.A. Hainfellner and B. Kepplinger
International Journal of Tryptophan Research 2012:5 49-64
Original Research | Published on 13 Dec 2012



Fate of Dietary Tryptophan in Young Japanese Women
Chiaki Hiratsuka, Tsutomu Fukuwatari and Katsumi Shibata
International Journal of Tryptophan Research 2012:5 33-47
Original Research | Published on 30 Oct 2012



A Brief Historic Overview of Clinical Disorders Associated with Tryptophan: The Relevance to Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM)
Adele Blankfield
International Journal of Tryptophan Research 2012:5 27-32
Letter to Editor | Published on 17 Sep 2012



Kynurenine Pathway in Skin Cells: Implications for UV-Induced Skin Damage
Diba Sheipouri, Nady Braidy, and Gilles J. Guillemin,
International Journal of Tryptophan Research 2012:5 15-25
Short Review | Published on 03 Jul 2012



A Jerte Valley Cherry-Based Product as a Supply of Tryptophan
María Garrido, Javier Espino, Antonio F. Toribio-Delgado, Javier Cubero, Juan I. Maynar-Mariño, Carmen Barriga, Sergio D. Paredes and Ana B. Rodríguez
International Journal of Tryptophan Research 2012:5 9-14
Original Research | Published on 16 Apr 2012



Quinolinic Acid, an Endogenous Molecule Combining Excitotoxicity, Oxidative Stress and Other Toxic Mechanisms
Verónica Pérez-De La Cruz, Paul Carrillo-Mora and Abel Santamaría
International Journal of Tryptophan Research 2012:5 1-8
Review | Published on 23 Feb 2012



Stochastic Resonance Activity Influences Serum Tryptophan Metabolism in Healthy Human Subjects
Berthold Kepplinger, Halina Baran, Brenda Sedlnitzky-Semler, Nagy-Roland Badawi and Helene Erhart
International Journal of Tryptophan Research 2011:4 49-60
Original Research | Published on 08 Nov 2011



Kynurenine Pathway Hypothesis: The Nature of the Chronic Fatigue Syndrome (CFS) Revisited
Adele Blankfield
International Journal of Tryptophan Research 2011:4 47-48
Letter to Editor | Published on 31 Jul 2011



L-Tryptophan Production by Auxotrophic and Analogue Resistant Mutants of Aureobacterium flavescens
A. Roy and S.K. Mukhopadhyay
International Journal of Tryptophan Research 2011:4 39-46
Original Research | Published on 29 May 2011



Effects of Kynurenine Pathway Inhibition on NAD+ Metabolism and Cell Viability in Human Primary Astrocytes and Neurons
Nady Braidy, Gilles J. Guillemin and Ross Grant
International Journal of Tryptophan Research 2011:4 29-37
Original Research | Published on 08 May 2011 | Highly accessed (previous month)



Tryptophan Transport in Human Fibroblast Cells— A Functional Characterization
Vumma Ravi, Johansson Jessica, Lewander Tommy and Venizelos Nikolaos
International Journal of Tryptophan Research 2011:4 19-27
Original Research | Published on 19 Apr 2011



Modulation of Tryptophan Metabolism, Promotion of Neurogenesis and Alteration of Anxiety-Related Behavior in Tryptophan 2,3-Dioxygenase-Deficient Mice
Hiroshi Funakoshi, Masaaki Kanai, and Toshikazu Nakamura
International Journal of Tryptophan Research 2011:4 7-18
Meeting Report | Published on 11 Apr 2011



Tryptophan Oxidative Metabolism Catalyzed by Geobacillus Stearothermophilus: A Thermophile Isolated from Kuwait Soil Contaminated with Petroleum Hydrocarbons
Jassim M. Al-Hassan, Samira Al-Awadi, Sosamma Oommen, Abdulaziz Alkhamis and Mohammad Afzal
International Journal of Tryptophan Research 2011:4 1-6
Original Research | Published on 10 Jan 2011



Rapid Isocratic Liquid Chromatographic Separation and Quantification of Tryptophan and Six kynurenine Metabolites in Biological Samples with Ultraviolet and Fluorimetric Detection
Abdulla A-B Badawy and Christopher J Morgan
International Journal of Tryptophan Research 2010:3 175-186
Original Research | Published on 08 Dec 2010



Alzheimer’s and Seizures: Interleukin-18, Indoleamine 2,3-Dioxygenase and Quinolinic Acid
Anderson G and Ojala JO
International Journal of Tryptophan Research 2010:3 169-173
Hypothesis | Published on 15 Oct 2010



Understanding the Roles of the Kynurenine Pathway in Multiple Sclerosis Progression
Chai K. Lim, Bruce J. Brew, Gayathri Sundaram and Gilles J. Guillemin
International Journal of Tryptophan Research 2010:3 157-167
Review | Published on 25 Aug 2010



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What Your Colleagues Say About International Journal of Tryptophan Research
My experience with Int J Tryptophan Research has been excellent. The editors and reviewers were most helpful and very "open" intellectually given we were proposing a novel and counter-intuitive hypothesis. The administrative staff have been patient, quick, helpful and friendly. I would and have recommended this group of journals to colleagues.
Dr Adrian Williams (University Hospitals Birmingham, Birmingham, UK)
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