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Publication Date: 20 Oct 2011
Journal: Clinical Medicine Insights: Oncology
doi: 10.4137/CMO.S5977
Therapeutic advances changed dramatically in 2010 with the U.S. FDA approval of the autologous cellular immunotherapy sipuleucel-T for the treatment of men with asymptomatic or minimally symptomatic metastatic CRPC. This is an updated review on the data regarding therapeutic options with particular focus on the emerging strategies for incorporating sipuleucel-T into this changing landscape
Most prostate cancer-related deaths occur in patients with castration-resistant prostate cancer (CRPC). Until recently, only therapy with docetaxel and prednisone has been shown to prolong survival in men with metastatic CRPC. With the United States Food and Drug Administration (US FDA) approvals of sipuleucel-T, cabazitaxel, and abiraterone acetate, all based on improvement in overall survival, the landscape for management of men with metastatic CRPC has dramatically changed. In this review we will discuss the pivotal clinical trial data leading to these approvals, with particular focus on the unique indication for sipuleucel-T and the implications for optimal management and sequencing of treatment in this patient population.
This is the first time we published an article in Substance Abuse: Research and Treatment, and we were pleased to find that the publishing staff were extremely helpful in guiding our submission through all the hoops. More important they answered our concerns without delay and where necessary made changes in the page proofs in accord with our wishes. I have published upwards of 80 or 90 articles, chapters and edited volumes, and I have never worked with a publishing staff who were as responsive as the staff of SART. At first, we wondered how fast a team of editors half a globe away were going to receive our edits and act on them – the answer was “immediately.” They must never sleep down under.Dr Jan Howard (Senior Scientific Advisor, Westat Corporation, Rockville, Maryland) What Your Colleagues Say
Copyright © 2012 Libertas Academica Ltd (except open access articles and accompanying metadata and supplementary files.)
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