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JOURNAL

Biomarker Insights


An international, peer reviewed, open access journal that aims to support those engaged in biomarker research, by providing rapid communication of the latest advances in the application of biomarkers toward discovery of new knowledge and clinical application of that knowledge.

Editor in Chief: Dr. Karen Pulford

ISSN: 1177-2719

Processing Speed: High quality, constructive peer review and rapid editorial decision within an average of four weeks.



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Low Doses of Cisplatin Induce Gene Alterations, Cell Cycle Arrest, and Apoptosis in Human Promyelocytic Leukemia Cells
Venkatramreddy Velma, Shaloam R. Dasari and Paul B. Tchounwou
Biomarker Insights 2016:11 113-121
Original Research | Published on 24 Aug 2016



Plasminogen Activator System and Breast Cancer: Potential Role in Therapy Decision Making and Precision Medicine
Adel Gouri, Aoulia Dekaken, Khalid El Bairi, Arifa Aissaoui, Nihad Laabed, Mohamed Chefrour, Joseph Ciccolini, Gérard Milano and Sadek Benharkat
Biomarker Insights 2016:11 105-111
Review | Published on 16 Aug 2016



Significance of HbA1c Test in Diagnosis and Prognosis of Diabetic Patients
Shariq I. Sherwani, Haseeb A. Khan, Aishah Ekhzaimy, Afshan Masood and Meena K. Sakharkar
Biomarker Insights 2016:11 95-104
Review | Published on 03 Jul 2016



Changes in Urinary and Serum Levels of Novel Biomarkers after Administration of Gadolinium-based Contrast Agents
Habib Mawad, Louis-Philippe Laurin, Jean-François Naud, François A. Leblond, Nathalie Henley, Michel Vallée, Vincent Pichette and Martine Leblanc
Biomarker Insights 2016:11 91-94
Short Report | Published on 29 Jun 2016



Role of Biomarkers in the Diagnosis, Risk Assessment, and Management of Pulmonary Hypertension
Vanessa Rameh and Antoine Kossaify
Biomarker Insights 2016:11 85-89
Short Review | Published on 23 Jun 2016



Precision-Cut Kidney Slices as a Tool to Understand the Dynamics of Extracellular Matrix Remodeling in Renal Fibrosis
Federica Genovese, Zsolt S. Kàrpàti, Signe H. Nielsen and Morten A. Karsdal
Biomarker Insights 2016:11 77-84
Original Research | Published on 22 May 2016



Prediction of the Risk for Essential Hypertension among Carriers of C825T Genetic Polymorphism of G Protein β3 (GNB3) Gene
Neveen Salah El Din Hemimi, Amal A. Mansour and Mona Mohamed Abdelsalam
Biomarker Insights 2016:11 69-75
Original Research | Published on 17 May 2016



Evaluation of Ischemia-Modified Albumin, Malondialdehyde, and Advanced Oxidative Protein Products as Markers of Vascular Injury in Diabetic Nephropathy
Afzal Ahmad, Poornima Manjrekar, Charu Yadav, Ashish Agarwal, Rukmini Mysore Srikantiah and Anupama Hegde
Biomarker Insights 2016:11 63-68
Original Research | Published on 02 May 2016



Proteomic Changes in the Plasma of Broiler Chickens with Femoral Head Necrosis
Balamurugan Packialakshmi, Rohana Liyanage, Jackson O. Lay, Jr., Ronald Okimoto and Narayan C. Rath
Biomarker Insights 2016:11 55-62
Original Research | Published on 27 Apr 2016



Risk of Infectious Complications in Hemato-Oncological Patients Treated with Kinase Inhibitors
Mark Reinwald, Tobias Boch, Wolf-Karsten Hofmann and Dieter Buchheidt
Biomarker Insights 2015:Suppl. 3 55-68
Review | Published on 21 Apr 2016



Heme Oxygenase Activity Correlates with Serum Indices of Iron Homeostasis in Healthy Nonsmokers
Andrew J. Ghio and Dina M. Schreinemachers
Biomarker Insights 2016:11 49-54
Original Research | Published on 19 Apr 2016



Urine Proteome Biomarkers in Kidney Diseases. I. Limits, Perspectives, and First Focus on Normal Urine
Laura Santucci, Maurizio Bruschi, Giovanni Candiano, Francesca Lugani, Andrea Petretto, Alice Bonanni and Gian Marco Ghiggeri
Biomarker Insights 2016:11 41-48
Review | Published on 16 Mar 2016



Management of Chronic Myeloid Leukemia Patients Resistant to Tyrosine Kinase Inhibitors Treatment
Agnieszka Wieczorek and Lutz Uharek
Biomarker Insights 2015:Suppl. 3 49-54
Review | Published on 18 Feb 2016



Histone H3 Phosphorylation in Human Skin Histoculture as a Tool to Evaluate Patient’s Response to Antiproliferative Drugs
Fernando Ugarte, Katherine Porth and Svetlana Sadekova
Biomarker Insights 2015:Suppl. 4 73-76
Original Research | Published on 18 Feb 2016



Challenges and Current Efforts in the Development of Biomarkers for Chronic Inflammatory and Remodeling Conditions of the Lungs
Gabriele Grunig, Aram Baghdassarian, Sung-Hyun Park, Serhiy Pylawka, Bertram Bleck, Joan Reibman, Erika Berman-Rosenzweig and Nedim Durmus
Biomarker Insights 2015:Suppl. 4 59-72
Review | Published on 16 Feb 2016 | Video abstract



DNA Subtraction of In Vivo Selected Phage Repertoires for Efficient Peptide Pathology Biomarker Identification in Neuroinflammation Multiple Sclerosis Model
Karina Vargas-Sanchez, Antonios Vekris, and Klaus G. Petry
Biomarker Insights 2016:11 19-29
Original Research | Published on 16 Feb 2016



Assessment of Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Retinol-Binding Protein 4 (RBP4) in Type 2 Diabetic Patients with Nephropathy
Mohamed H. Mahfouz, Adel M. Assiri and Mohammed H. Mukhtar
Biomarker Insights 2016:11 31-40
Original Research | Published on 16 Feb 2016



Isolation of Circulating Tumor Cells from Multiple Epithelial Cancers with ApoStream for Detecting (or Monitoring) the Expression of Folate Receptor Alpha
Daniel J. O'Shannessy, Darren W. Davis, Kenna Anderes and Elizabeth B. Somers
Biomarker Insights 2016:11 7-18
Original Research | Published on 01 Feb 2016



Beyond the Ribosome: Extra-translational Functions of tRNA Fragments
Kevin W. Diebel, Kun Zhou, Aaron B. Clarke and Lynne T. Bemis
Biomarker Insights 2016:Suppl. 1 1-8
Review | Published on 28 Jan 2016



Bioinformatics Resources for MicroRNA Discovery
Alyssa C. Moore, Jonathan S. Winkjer and Tsai-Tien Tseng
Biomarker Insights 2015:Suppl. 4 53-58
Review | Published on 18 Jan 2016



MicroRNAs Expressed during Viral Infection: Biomarker Potential and Therapeutic Considerations
Jennifer Louten, Michael Beach, Kristina Palermino, Maria Weeks and Gabrielle Holenstein
Biomarker Insights 2015:Suppl. 4 25-52
Review | Published on 18 Jan 2016



Urinary Vitamin D-Binding Protein as a Biomarker of Steroid-Resistant Nephrotic Syndrome
Michael R. Bennett, Angad Pordal, Christopher Haffner, LaTawnya Pleasant, Qing Ma and Prasad Devarajan
Biomarker Insights 2016:11 1-6
Original Research | Published on 13 Jan 2016



Modeling Kidney Disease with iPS Cells
Benjamin S. Freedman
Biomarker Insights 2015:Suppl. 1 153-169
Review | Published on 22 Dec 2015



Patterns of Local and Systemic Cytokines in Bacterial Meningitis and its Relation with Severity and Long-Term Sequelae
Federico Perdomo-Celis, Miguel A. Torres, Henry Ostos, Javier Gutierrez-Achury, Víctor Molano, Luis F. Durán, Guillermo González, and Carlos F. Narváez
Biomarker Insights 2015:10 125-131
Original Research | Published on 20 Dec 2015



miRNAs As Diagnostic and Prognostic Biomarkers in Pancreatic Ductal Adenocarcinoma and Its Precursor Lesions: A Review
Bárbara Alemar, Cleandra Gregório, and Patricia Ashton-Prolla
Biomarker Insights 2015:10 113-124
Review | Published on 13 Dec 2015



Efficacy of Dasatinib in a CML Patient in Blast Crisis with F317L Mutation: A Case Report and Literature Review
E.V. Morozova, Y.Y. Vlasova, M.V. Pryanishnikova, K.V. Lepik and B.V. Afanasyev
Biomarker Insights 2015:Suppl. 3 43-47
Review | Published on 08 Dec 2015



High Expression of Three-Gene Signature Improves Prediction of Relapse-Free Survival in Estrogen Receptor-Positive and Node-Positive Breast Tumors
Arvind Thakkar, Hemanth Raj, Ravishankar, Bhaskaran Muthuvelan, Arun Balakrishnan and Muralidhara Padigaru
Biomarker Insights 2015:10 103-112
Original Research | Published on 30 Nov 2015



Introductory Editorial: Tyrosine Kinases in Cancer
Olga Blau, Boris Afanasyev, Igor W. Blau
Biomarker Insights 2015:Suppl. 3 41-42
Editorial | Published on 02 Nov 2015



MicroRNA-155 and Its Role in Malignant Hematopoiesis
Prajnya Ranganath
Biomarker Insights 2015:10 95-102
Review | Published on 22 Oct 2015



Decreased Phosphorylated Protein Kinase B (Akt) in Individuals with Autism Associated with High Epidermal Growth Factor Receptor (EGFR) and Low Gamma-Aminobutyric Acid (GABA)
Anthony J. Russo
Biomarker Insights 2015:10 89-94
Original Research | Published on 14 Oct 2015



More than a Decade of Tyrosine Kinase Inhibitors in the Treatment of Solid Tumors: What We Have Learned and What the Future Holds
Maria Vergoulidou
Biomarker Insights 2015:Suppl. 3 33-40
Review | Published on 08 Oct 2015



Evaluation of Candidate Biomarkers of Type 1 Diabetes via the Core for Assay Validation
Cate Speake and Jared M. Odegard
Biomarker Insights 2015:Suppl. 4 19-24
Review | Published on 29 Sep 2015



Biomarkers for Sepsis: What Is and What Might Be?
Bethany M. Biron, Alfred Ayala and Joanne L. Lomas-Neira
Biomarker Insights 2015:Suppl. 4 7-17
Review | Published on 15 Sep 2015



Directed Differentiation of Pluripotent Stem Cells into Kidney
Ryuji Morizane and Albert Q. Lam
Biomarker Insights 2015:Suppl. 1 147-152
Review | Published on 13 Sep 2015



Emerging Role of Tyrosine Kinases as Drugable Targets in Cancer
Il-Kang Na and Philipp le Coutre
Biomarker Insights 2015:Suppl. 3 29-31
Commentary | Published on 10 Sep 2015



Genomic, Proteomic, and Metabolomic Data Integration Strategies
Kwanjeera Wanichthanarak, Johannes F. Fahrmann and Dmitry Grapov
Biomarker Insights 2015:Suppl. 4 1-6
Review | Published on 07 Sep 2015 | Editor in Chief endorsed



Urinary Neutrophil Gelatinase-Associated Lipocalin to Monitor Lupus Nephritis Disease Activity
Hani Susianti, Jullyanny W. Wijaya, Ati Rastini, Kusworini Handono, Atma Gunawan and Handono Kalim
Biomarker Insights 2015:10 81-87
Original Research | Published on 06 Sep 2015



BCR-ABL Mutation-Guided Therapy for CML Blast Crisis: A Case Report
Benjamin N. Ostendorf, Hendrik Nogai, Claudia D. Baldus, Thomas Burmeister, and Renate Arnold
Biomarker Insights 2015:Suppl. 3 25-28
Case Report | Published on 30 Aug 2015



Stem Cells and Progenitor Cells for Tissue-Engineered Solutions to Congenital Heart Defects
Yang Gao and Jeffrey G. Jacot
Biomarker Insights 2015:Suppl. 1 139-146
Review | Published on 26 Aug 2015



von Willebrand Factor Propeptide: A Potential Disease Biomarker Not Affected by ABO Blood Groups
Mahat Marianor, Abdullah Wan Zaidah and C.H. Che Maraina
Biomarker Insights 2015:10 75-79
Original Research | Published on 23 Aug 2015



Introductory Editorial: Stem Cell Biology
David Brafman, Stuart Campbell, Albert Q. Lam, Jean J. Kim, Mehdi Nikkhah, Sarah Stabenfeldt
Biomarker Insights 2015:Suppl. 1 133-137
Editorial | Published on 23 Aug 2015



Autoantibody Profiles in Collagen Disease Patients with Interstitial Lung Disease (ILD): Antibodies to Major Histocompatibility Complex Class I-Related Chain A (MICA) as Markers of ILD
Hiroshi Furukawa, Shomi Oka, Kota Shimada, Kiyoe Masuo, Fumiaki Nakajima, Shunichi Funano, Yuki Tanaka, Akiko Komiya, Naoshi Fukui, Tatsuya Sawasaki, Kenji Tadokoro, Masato Nose, Naoyuki Tsuchiya and Shigeto Tohma
Biomarker Insights 2015:10 63-73
Original Research | Published on 16 Aug 2015



Role of Tyrosine Kinase Inhibitors in Indolent and Other Mature B-Cell Neoplasms
Nadine Kutsch, Reinhard Marks, Richard Ratei, Thomas K. Held and Martin Schmidt-Hieber
Biomarker Insights 2015:Suppl. 3 15-23
Review | Published on 16 Aug 2015



Class III Receptor Tyrosine Kinases in Acute Leukemia – Biological Functions and Modern Laboratory Analysis
Rimma Berenstein
Biomarker Insights 2015:Suppl. 3 1-14
Review | Published on 05 Aug 2015



Analysis of Lung Flute–collected Sputum for Lung Cancer Diagnosis
Jian Su, Nigar Anjuman, Maria A. Guarnera, Howard Zhang, Sanford A. Stass and Feng Jiang
Biomarker Insights 2015:10 55-61
Original Research | Published on 04 Aug 2015



Applications of iPSCs in Cancer Research
Jean J. Kim
Biomarker Insights 2015:Suppl. 1 125-131
Review | Published on 29 Jul 2015



Self-organized Kidney Rudiments: Prospects for Better in vitro Nephrotoxicity Assays
Jamie A. Davies
Biomarker Insights 2015:Suppl. 1 117-123
Concise Review | Published on 16 Jul 2015



Synthetic Extracellular Microenvironment for Modulating Stem Cell Behaviors
Prafulla Chandra and Sang Jin Lee
Biomarker Insights 2015:Suppl. 1 105-116
Review | Published on 17 Jun 2015



Prospects for In Vitro Myofilament Maturation in Stem Cell-Derived Cardiac Myocytes
Jonas Schwan and Stuart G. Campbell
Biomarker Insights 2015:Suppl. 1 91-103
Commentary | Published on 10 Jun 2015



Immunomodulatory Effects of Probiotic Supplementation in Schizophrenia Patients: A Randomized, Placebo-Controlled Trial
Jakub Tomasik, Robert H. Yolken, Sabine Bahn, and Faith B. Dickerson
Biomarker Insights 2015:10 47-54
Original Research | Published on 01 Jun 2015





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I would like to extend my gratitude for creating the next generation of a scientific journal -- the science journal of tomorrow. The entire process bespoke of exceptional efficiency, celerity, professionalism, competency, and service.
Dr Jason B. Nikas (Medical School University of Minnesota, Minneapolis, MN, USA)
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