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JOURNAL

International Journal of Tryptophan Research

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L -Tryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications

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Publication Date: 23 Mar 2009

Journal: International Journal of Tryptophan Research

Citation: International Journal of Trytophan Research 2009:2 45-60

Abstract

An essential component of the human diet, L-tryptophan is critical in a number of metabolic functions and has been widely used in numerous research and clinical trials. This review provides a brief overview of the role of L-tryptophan in protein synthesis and a number of other metabolic functions. With emphasis on L-tryptophan’s role in synthesis of brain serotonin, details are provided on the research uses of L-tryptophan, particularly L-tryptophan depletion, and on clinical trials that have been conducted using L-tryptophan supplementation. The ability to change the rates of serotonin synthesis in the brain by manipulating concentrations of serum tryptophan is the foundation of much research. As the sole precursor of serotonin, experimental research has shown that L-tryptophan’s role in brain serotonin synthesis is an important factor involved in mood, behavior, and cognition. Furthermore, clinical trials have provided some initial evidence of L-tryptophan’s efficacy for treatment of psychiatric disorders, particularly when used in combination with other therapeutic agents.


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What Your Colleagues Say About International Journal of Tryptophan Research
Publishing in the International Journal of Tryptophan Research was a smooth and efficient process. I was kept extremely well informed of the progress of my publication and the review process was thorough, positive and formative. I look forward to repeating the experience in the near future.
Dr Simon P. Jones (St Vincent’s Center for Applied Medical Research, University of New South Wales, Sydney, Australia)
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